5-HTP, the intermediate metabolite between the amino acid L-tryptophan and serotonin, is extracted from the seed of an African plant (Griffonia simplicifolia). 5-HTP readily crosses the blood-brain barrier and increases central nervous system (CNS) synthesis of serotonin. Serotonin can affect sleep, appetite, temperature, sexual behaviour, and pain sensation. Serotonin also has a significant role in depression, anxiety, and aggression. 5-HTP is one of the few approved natural therapies for fibromyalgia with the possibility of reducing pain severity, morning stiffness, and sleeplessness. 5-HTP has been shown to increase neurotransmitting catecholamines such as dopamine and norepinephrine that are synthesized from tyrosine. There is speculation that increasing the availability of tyrosine to the brain allows increased neurotransmitter synthesis, which helps to counter the negative effects of stress. The addition of B-vitamins to this formula provides additional synergistic effects as they enhance the metabolism of amino acids. Our NOW natural and organic Supplements are an effective way to ensure you and your loved ones are getting essential vitamins, minerals and nutrients for daily optimal health. Since 2000, the NOW brand has been supporting Canadians with a mission to provide products that empower people to lead healthier lives. 70% of the NOW products in Canada are made or packaged in Guelph, Ontario, employing hundreds of Canadians from coast to coast. NOW performs 31,000 quality tests every month to ensure you get the highest quality supplements at the best price possible. Our promise - what is on the label, is precisely what is in the bottle.